Today we will introduce the curcumin extraction and purification.
1 – The physical and chemical properties of curcumin
Curcumin compounds is the main ingredient in curcumin, take off the methoxyl group of curcumin and double methoxyl group of curcumin, are the primary ingredients, pharmacological activity of curcuma play and curcumin in curcumin compounds accounted for about 70%, is one of the most important active ingredient.The main chain of the curcumin formula for unsaturated aliphatic and aromatic groups, soluble in methanol, ethanol, acetone, ethyl acetate and lye, insoluble in water, slightly soluble in benzene and ethyl ether, is a light-sensitive material.
2 – Curcumin extraction process
Reports the extraction process of curcumin is more, there are mainly alcohol extraction process, acid and alkali extraction, enzymatic and sodium salicylate method, supercritical CO2 extraction, etc.
2.1 – Alcohol extraction process
In normal temperature or high temperature conditions, with different concentrations of ethanol extraction of curcumin (commonly 70% ~ 80%), namely, by the methods of extraction, diacolation method, etc., and can use ultrasonic , microwave, surfactants and other auxiliary extraction.Alcohol formulation higher extraction yield, simple process, the reaction conditions are easy to control, easy popularization and application in production.
2.2 – Alkali method: Using curcumin contained phenol hydroxyl soluble in alkali, the principle of the curcumin were extracted with a certain concentration of sodium hydroxide solution, then with dilute hydrochloric acid pH adjustment, make curcumin exhalation, curcumin crude product.This method get curcumin crude products easy to dry, but curcumin easily under the condition of alkaline decomposition, decomposition rate from pH 7.45 with the augmentation of the alkaline rose sharply, to the maximum when the pH 10.2, the nature of curcumin products is not stable, and alkali extraction process will dissolve out a large amount of starch, affect the refining process of the next step, acid and alkali method curcumin yield is low.
2.3 – enzymatic application of cellulase and pectinase compound enzyme in turmeric stromal cell wall and cell materials such as cellulose, hemicellulose degradation, cause partial loose mesenchymal cell wall and cell structure, expansion, change such as collapse, thus improve the curcumin withdrawal rate, and then to heat up, use alkaline extraction.But the enzyme reaction condition and alkali extraction condition control makes it hard for this law in the popularization and application in production.
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Ok.Let’s end here. I will pull out more about chemical raw materials later.Thanks!